The Pathology Specimen Locator (PSL) is a distributed database within DF/HCC affiliated instituations indexing millions of discarded
human specimens that can be used for translational studies such as biomarker discovery and
validation. Investigators use PSL to locate paraffin and frozen specimens available across the
Harvard pathology departments. When specimens matching the study criteria are located,
investigators can request tissue and pathology services.
Many scientists are calling for a closer connection between research and routine care delivery.
Human specimens are routinely collected yet infrequently shared for research studies such as
biomarker discovery and validation. While many reports suggest that access to well-characterized
human tissues represents a valuable research resource in the post-genomic era, few studies have
access to tissue quantities large enough for high- throughput experimentation. Similarly, the
related clinical information remains invaluable yet oftentimes inaccessible to investigators. To
address these needs, the Pathology Specimen Locator supports translational research studies that
require human specimens and related clinical information.