Concept and Research
Much is made in this era of translational research of the need to cross boundaries between biomedical research organizations that individually have insufficient patient-subjects. Concurrently, the noisiness and high dimensionality of genome scale measurements has made it all the more pressing to increase sample size to overcome problems of false discovery, and irreproducibility that stem in part from insufficiently powered studies. Building on the success of SPIN, the Pathology Specimen Locator (PSL) is a core developed to facilitate translational research requiring human specimens. The PSL is a distributed network of databases containing de-identified information on archived specimens from IRB-approved repositories within Dana-Farber/Harvard Cancer Center affiliated institutions.